Pharma major AstraZeneca said on Monday that an interim analysis of clinical trials of its COVID-19 vaccine in the UK and Brazil showed that it was 70 per cent effective on average, becoming the third drugmaker to announce promising results to contain the deadly virus.

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The Covid-19 vaccine, developed with the University of Oxford, showed 90 per cent efficacy in one dosing regimen when the vaccine was given as a half dose, followed by a full dose at least a month later, and another dosing regimen showed 62 per cent efficacy when given as two full doses at least one month apart, AstraZeneca said in a statement.

"The combined analysis from both dosing regimens resulted in an average efficacy of 70 per cent," it added.

An independent Data Safety Monitoring Board determined that the analysis met its primary endpoint showing protection from COVID-19 occurring 14 days or more after receiving two doses of the vaccine, AstraZeneca said.

No serious safety events related to the vaccine have been confirmed. The ChAdOx1 nCoV-2019 or codenamed AZD1222 was well tolerated across both dosing regimens, it said.

The company "will now immediately prepare the regulatory submission of the data to authorities around the world that have a framework in place for conditional or early approval," the statement said.

AstraZeneca will seek an Emergency Use Listing from the World Health Organisation for an accelerated pathway to vaccine availability in low-income countries, it added.

"These findings show that we have an effective vaccine that will save many lives. Excitingly, we've found that one of our dosing regimens may be around 90 per cent effective and if this dosing regimen is used, more people could be vaccinated with planned vaccine supply," explained Professor Andrew Pollard, Director of the Oxford Vaccine Group and Chief Investigator of the Oxford Vaccine Trial.

The result of the Oxford University vaccine compares with the Pfizer and Moderna vaccines, which were recently shown to be 95 per cent and 94.5 per cent effective, respectively. The Oxford University vaccine is comparatively cheaper and easier to store.

"Today marks an important milestone in our fight against the pandemic. This vaccine's efficacy and safety confirm that it will be highly effective against COVID-19 and will have an immediate impact on this public health emergency," AstraZeneca Chief Executive Officer Pascal Soriot said.

"Furthermore, the vaccine's simple supply chain and our no-profit pledge and commitment to broad, equitable and timely access means it will be affordable and globally available, supplying hundreds of millions of doses on approval," Soriot said.

Serum Institute of India (SII) which is conducting clinical trials of AstraZeneca's COVID-19 vaccine candidate in India welcomed the latest developments.

"I am delighted to hear that, Covishield, a low-cost, logistically manageable & soon to be widely available, #COVID19 vaccine, will offer protection up to 90% in one type of dosage regime and 62% in the other dosage regime," SII CEO Adar Poonawalla tweeted.

The vaccine has been developed in around 10 months, a process that normally takes a decade.

AstraZeneca said it was making rapid progress in manufacturing with a capacity of up to 3 billion doses of the vaccine in 2021 on a rolling basis, pending regulatory approval.

"The vaccine can be stored, transported and handled at normal refrigerated conditions for at least six months and administered within existing healthcare settings," it added.

British Prime Minister Boris Johnson said, "Incredibly exciting news the Oxford vaccine has proved so effective in trials. There are still further safety checks ahead, but these are fantastic results."

Health Secretary Matt Hancock also expressed excitement and said that if everything goes to plan, the UK can start rolling out the vaccines as early as next month with bulk in early 2021.

More than 20,000 volunteers were involved in the trial, half in the UK and the rest in Brazil. There were 30 cases of COVID in people who had two doses of the vaccine and 101 cases in people who received a dummy injection.

When volunteers were given two "high" doses the protection was 62 per cent, but this rose to 90 per cent when people were given a "low" dose followed by a high one. It's not clear why there is a difference, which will be analysed further.

Professor Sarah Gilbert, Professor of Vaccinology at the University of Oxford, added: "The announcement today takes us another step closer to the time when we can use vaccines to bring an end to the devastation caused by SARS-CoV-2 (COVID-19)."

The clinical trials, enrolling over 24,000 participants from diverse racial and geographical groups in the UK, Brazil and South Africa, will now continue to final analysis.

Further trials are being conducted in India, the US, Kenya and Japan and the trial team expect to have under 60,000 participants by the end of the year, the university said.

The Oxford vaccine is made from a virus, which is a weakened version of a common cold virus (adenovirus), that has been genetically changed so that it is impossible for it to grow in humans.

Adenovirus vaccines have been researched and used extensively for decades and have the significant benefit that they are stable, easily manufactured, transported and stored at domestic fridge temperature (2-8 degrees C), meaning the vaccine, once approved, can be easily distributed using existing medical facilities and deployed very rapidly.

According to Johns Hopkins data, there are 58,696,029 COVID-19 cases and 13,88,724 deaths across the world.