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E-cigarette vaping harms mucus clearance, study suggests

E-cigarette vaping harms mucus clearance, study suggests

Sat, Jun 08, 2019

A new study highlights that e-cigarette vaping hampers the cleaning of mucus from the airways. The study published in the Journal of Respiratory and Critical Care Medicine also stated that a single session of vaping can deliver more nicotine to the airways than smoking one cigarette. Researchers report that exposing human airway cells to e-cigarette vapour containing nicotine in culture resulted in a decreased ability to move mucus or phlegm across the surface. This phenomenon is called "mucociliary dysfunction." Mucociliary dysfunction is a feature of many lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. "This study grew out of our team's research on the influence of tobacco smoke on mucus clearance from the airways," said senior author Matthias Salathe, University of Kansas Medical Center. Salathe added, "The question was whether vape containing nicotine had negative effects on the ability to clear secretions from the airways similar to tobacco smoke." Specifically, the study found that vaping with nicotine impairs ciliary beat frequency, dehydrates airway fluid and makes mucus more viscous or sticky. These changes make it more difficult for the bronchi, the main passageways to the lung, to defend themselves from infection and injury. The researchers note that a recent report found that young e-cigarette users who never smoked were at increased risk to develop chronic bronchitis, a condition characterized by chronic production of phlegm that is also seen in tobacco smokers. The study also found that nicotine produced these negative effects by stimulating the ion channel transient receptor potential ankyrin 1 (TRPA1). Blocking TRPA1 reduced the effects of nicotine on clearance in both the human cells in culture and in the sheep. "Vaping with nicotine is not harmless as commonly assumed by those who start vaping, At the very least, it increases the risk of chronic bronchitis." Dr Salathe said.

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Early life challenges affect how children focus on activities

Early life challenges affect how children focus on activities

Fri, Jun 07, 2019

Facing adversities and challenges during the early years of lives affect children's executive function skills and their ability to focus and organize tasks, recent findings suggest. According to the study, experiences such as poverty, residential instability, or parental divorce or substance abuse, can lead to changes in a child's brain chemistry, muting the effects of stress hormones. These hormones are responsible to help us face challenges, stress, or to simply help us "get up and go."Together, these impacts to executive function and stress hormones create a snowball effect, adding to social and emotional challenges that can continue through childhood. As part of this study, a team of researchers examined how adversity can change the ways children develop. The study, published in the Journal of Development and Psychopathology, evaluated 306 children at intervals over more than two years, starting when participants were around 3 years old, up to age 5 1/2. Children were from a range of racial, ethnic and socioeconomic backgrounds, with 57 per cent considered lower income or near poverty. Income was a key marker for adversity. In addition, the children's mothers were surveyed about other risk factors that have been linked to poor health and behaviour outcomes in children, including family transitions, residential instability, and negative life events such as abuse or the incarceration of a parent. Against these data, Lengua's team tested children's executive function skills with a series of activities, and, through saliva samples, a stress-response hormone called diurnal cortisol. In another activity, children interact with two puppets -- a monkey and a dragon -- but are supposed to follow only the instructions given by the monkey. When children are better at following instructions in these and similar activities, they tend to have better social skills and manage their emotions when stressed. Children who did well on these tasks also tended to have more typical patterns of diurnal cortisol. But children who were in families that had lower income and higher adversity tended to have both lower executive function and an atypical diurnal cortisol pattern. Each of those contributed to more behaviour problems and lower social-emotional competence in children when they were about to start kindergarten.

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